No clinically relevant differences in the adverse event profile were observed for pediatric patients aged to 16 years as compared with adult patients. If treatment with atropine is not successful, Lopressor should be discontinued, and cautious administration of isoproterenol or installation of cardiac pacemaker should be considered. If cardiac failure continues, despite adequate digitalization and diuretic therapy, Lopressor should be withdrawn. Precautions General Toprol-XL should be used with caution in patients with impaired hepatic function. Beta blocker levels, risk of hypotension, bradycardia, AV block, excessive beta blockade metoprolol odavad uleoo hepatic metab. Difficulty in restarting and maintaining the heart beat has also been reported with beta-blockers. It is freely soluble in soluble in sparingly soluble in slightly soluble in dichloromethane and practically insoluble in ethylacetate, acetone, diethylether and heptane.