This effect can occur when the alpha2-agonist is abruptly withdrawn. Fetotoxicity was present at 43 172 times the MRHD of H, respectively, on body weight basis, and 35 times the MRHD of doses, respectively, on the basis of body surface area. Heart failure HF Use with caution in patients with compensated heart failure and monitor for worsening of the condition. While in many cases it is not known whether causal relationship exists between bisoprolol and these AEs, fedex consegna bisoprolol they are listed to alert the physician to possible relationship. Tell your doctor immediately if any of these unlikely but serious side effects occur: very slow heartbeat, severe dizziness, fainting, blue fingers toes, trouble breathing, mental mood changes such as confusion, mood swings, depression. Abrupt discontinuation of beta-blockade may exacerbate symptoms of hyperthyroidism and may also induce thyroid storm.